Pulmonary intravascular macrophages: their contribution to the mononuclear phagocyte system in 13 species.

The comparative biology of pulmonary intravascular macrophages.

Pulmonary intravascular macrophages are an important part of the mononuclear phagocyte system in some species of mammals, mainly sheep and other ruminants, pigs, and horses. These cells phagocytize foreign particles, cell debris and pathogens that pass through the pulmonary circulation. Species with intravascular macrophages localize intravenously injected tracer particles and bacteria predomin...

Endotoxemia enhances pulmonary mononuclear cell uptake of circulating particles and pathogens in a species without pulmonary intravascular macrophages.

Human and Mouse Mononuclear Phagocyte Networks: A Tale of Two Species?

Dendritic cells (DCs), monocytes, and macrophages are a heterogeneous population of mononuclear phagocytes that are involved in antigen processing and presentation to initiate and regulate immune responses to pathogens, vaccines, tumor, and tolerance to self. In addition to their afferent sentinel function, DCs and macrophages are also critical as effectors and coordinators of inflammation and ...

Pulmonary intravascular macrophages: a review of immune properties and functions.

Pulmonary intravascular macrophages (PIMs) are mononuclear cells found apposed to the lung capillary endothelium in a number of mammalian species. Although first described in the 1970s, it was not until the 1980s that they were more completely described. In several species of veterinary interest (bovine, porcine, ovine, and feline), PIMs are very important in blood clearance, which is not the c...

Transcriptome profiling of primary murine monocytes, lung macrophages and lung dendritic cells reveals a distinct expression of genes involved in cell trafficking

BACKGROUND Peripheral blood monocytes (PBMo) originate from the bone marrow, circulate in the blood and emigrate into various organs where they differentiate into tissue resident cellular phenotypes of the mononuclear phagocyte system, including macrophages (Mphi) and dendritic cells (DC). Like in other organs, this emigration and differentiation process is essential to replenish the mononuclea...